Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AMI Key lab of Chinese Medicine in Guangzhou, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, China. Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China. First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China. Key Laboratory of Chinese Internal Medicine of ME and Beijing, Beijing University of Chinese Medicine, Beijing, China. Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China. minzhouzhang@aliyun.com. AMI Key lab of Chinese Medicine in Guangzhou, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China. minzhouzhang@aliyun.com. 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Yuexiu District, Guangzhou, 510120, China. minzhouzhang@aliyun.com. Translational Medicine, Hospital for Sick Children, University of Toronto, Toronto, Canada.